The retinal pigment epithelial layer is a single layer of cells containing a network of capillaries interspersed with granules of pigment. Sometimes, granules of pigment clump together in unusual bet well-defined patterns. When viewed via fluorescein angiography (FA), they can be categorized as pattern-specific dystrophies. A reticular pattern of pigmentation occurs when clumped pigment granules throughout the pigment epithelial layer resemble a “fishnet with knots”. This is sometimes referred to as a reticular dystrophy. Usually unusual patterns of pigmentation are harmless and do not alter vision. Correct identification and diagnosis is important, however, because the images of these pigmentation patterns can sometimes simulate other, more serious conditions of the retina.